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Manganese Gluconate

A bioavailable manganese salt that activates manganese superoxide dismutase — the mitochondrial antioxidant — and supports collagen synthesis through proline hydroxylation.

AntioxidantCollagen supportMineral cofactor
✓ Safe

What is it?

The gluconate salt of manganese, providing Mn²⁺ ions chelated to gluconic acid for improved solubility and skin compatibility. Gluconate salts are a preferred delivery form for mineral cosmetic actives.

Activates MnSOD to protect skin cells from mitochondrial oxidative stress, supports proline recycling for efficient collagen production, and contributes to glycosaminoglycan synthesis.

Key Benefits

✦
Mitochondrial Antioxidant
MnSOD is the first line of defence against mitochondrial superoxide radicals. Manganese supplementation supports this critical enzyme during UV and pollution stress.
◈
Proline Recycling
As a cofactor for prolidase, manganese ensures efficient recovery of hydroxyproline from collagen breakdown, making it available for new collagen synthesis.
✧
GAG Synthesis
Required for glycosyltransferases that build the glycosaminoglycan chains attached to proteoglycans, supporting the dermal matrix.

Suitable for

All skin typesUV-exposed skinMature skin

Main Actions

✓ Antioxidant enzyme activation✓ Collagen support✓ ECM synthesis
Low Concentration Requirement

Manganese is effective at very low concentrations in skincare — typically 0.01–0.1%. At higher concentrations it can be pro-oxidant. Gluconate chelation helps ensure controlled, safe delivery at effective doses.

Found in these products
La Roche-Posay Cicaplast Baume B5

Frequently Asked Questions

What does Manganese Gluconate do for skin?
Activates MnSOD to protect skin cells from mitochondrial oxidative stress, supports proline recycling for efficient collagen production, and contributes to glycosaminoglycan synthesis.
Who should use Manganese Gluconate?
Manganese Gluconate is suitable for: All skin types, UV-exposed skin, Mature skin.
Are there any warnings about Manganese Gluconate?
Manganese is effective at very low concentrations in skincare — typically 0.01–0.1%. At higher concentrations it can be pro-oxidant. Gluconate chelation helps ensure controlled, safe delivery at effective doses.

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