Soothing

Madecassoside

Purified active of Centella asiatica — madecassoside is the most researched glycoside of Centella asiatica with confirmed ability to stimulate collagen synthesis, accelerate healing, and soothe inflamed skin.

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✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Madecassoside — triterpene glycoside isolated from Centella asiatica (gotukola). Chemically, it is a glycoside of madecassic acid (3β,6β-olean-12-ene). Unlike raw centella extract, madecassoside is a purified molecule with concentrated activity and reproducible composition. Mechanisms of action: 1) stimulates the synthesis of collagen I and IV through activation of TGF-β1 in fibroblasts, 2) inhibits MMP (matrix metalloproteinases) that degrade collagen, 3) reduces inflammation by inhibiting NF-κB and key pro-inflammatory cytokines (IL-1β, TNF-α), 4) promotes the formation of proper collagen network architecture during healing. Used in medical products for wound healing and post-procedural recovery.

Serums and balms for recovery after aggressive procedures (peels, laser, microneedling). Products for sensitive and reactive skin. Effective in combination with ceramides, panthenol, and niacinamide to support the barrier. Concentration 0.1–2%.

Key Benefits

✦

Stimulation of collagen synthesis and recovery

Madecassoside activates TGF-β1 signaling in fibroblasts, triggering the synthesis of procollagen and collagen types I and IV. Clinical studies: 0.1% madecassoside accelerates wound healing and skin recovery after procedures. Inhibition of MMP (matrix metalloproteinases) additionally protects already synthesized collagen from degradation.

◈

Powerful anti-inflammatory and soothing action

Inhibits NF-κB — the central transcription factor of inflammation, reducing levels of IL-1β, IL-6, and TNF-α. Clinical data confirm effectiveness in atopic dermatitis, post-inflammatory sensitivity, and reactions after procedures. Especially effective in combination with asiaticoside — another active of centella.

✧

Acceleration of healing and support of the barrier

Madecassoside promotes proper formation of granulation tissue and normalizes keratinocyte migration during epidermal recovery. Used in medical preparations (Madecassol) for the treatment of chronic wounds and scars. Post-procedural application reduces skin recovery time and lowers the risk of post-inflammatory hyperpigmentation.

Suitable for

sensitive skindamaged and recovering skinskin after proceduresskin with atopic dermatitis

Main Actions

✓ stimulation of collagen synthesis✓ anti-inflammatory action✓ acceleration of healing

Madecassoside vs Centella extract

Centella asiatica extract — a mixture of triterpenes (madecassoside, asiaticoside, madecassic acid, asiatic acid) in unstable ratios depending on the plant. Madecassoside — a purified molecule with standardized content and predictable effect. More expensive to produce, hence less common, but in clinical studies, madecassoside shows the most consistent results. Products like 'Centella 100' or 'CICA' usually contain a mixture of all actives.

CategorySoothing Ingredients

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