Exfoliant

Gluconolactone

PHA acid with the gentlest action — gluconolactone exfoliates, hydrates, and strengthens the barrier simultaneously. An ideal alternative to AHA for sensitive skin: the effect is similar to glycolic, but without irritation and increased photosensitivity.

PHAExfoliationHydrationSensitive skin

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Gluconolactone — a lactone of gluconic acid, belongs to the class of polyhydroxy acids (PHA). The large molecule (MW ~178 Da, compared to ~76 in glycolic) penetrates slowly and evenly, without peak irritation. It contains several hydroxyl groups — hence the dual action: chemical exfoliant + hygroscopic moisturizer. Naturally occurs in honey and fermented products.

The safest chemical exfoliant in cosmetics. Used in toners, serums, cleansers for sensitive and rosacea-prone skin. Can be combined with retinol, niacinamide, and most active ingredients.

Key Benefits

✦

Gentle exfoliation without irritation

Breaks down desmosomes between corneocytes, accelerating the shedding of dead cells without damaging the barrier. Clinical studies show that gluconolactone does not cause more irritation than placebo — unlike glycolic (15% irritation in AHA vs 0% in PHA).

◈

Hydration and barrier strengthening

Multiple OH groups bind water in the stratum corneum (humectant effect). Unlike AHA, PHA does not disrupt the barrier, but rather stimulates ceramide synthesis and strengthens the lipid organization between corneocytes.

✧

Antioxidant protection

Chelates metal ions (Fe²⁺, Cu²⁺), preventing oxidative reactions. Neutralizes free radicals — additional protection against photoaging. The combination of exfoliant + antioxidant is unique to PHA acids.

Suitable for

Sensitive skinRosacea-prone skinNormal skinMature skin

Main Actions

✓ Gentle exfoliation✓ Hydration✓ Antioxidant protection

PHA vs AHA: what is the difference?

AHA (glycolic, lactic) — fast deep penetration, strong exfoliation, possible irritation, photosensitivity. PHA (gluconolactone, lactobionic acid) — gradual penetration, gentler effect, no photosensitivity, suitable for sensitive skin. Gluconolactone can be used during the day without mandatory SPF, although SPF is always recommended.

CategoryExfoliants

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