Peptide

SH-Oligopeptide-2

SH-Oligopeptide-2 — a synthetic analogue of IGF-1 (Insulin-like Growth Factor 1) that stimulates the metabolism of fibroblasts and collagen synthesis. It differs from EGF analogues in its specificity to IGF receptors — complements EGF for a more complete anti-aging effect.

IGF-1 analoguefibroblastscollagen synthesisanti-aging

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

SH-Oligopeptide-2 (INCI: SH-Oligopeptide-2) — a synthetic oligopeptide analogue of IGF-1 (Somatomedin C). Natural IGF-1: a 70-amino acid polypeptide synthesized in the liver under the influence of GH (growth hormone). MW of natural IGF-1: ~7,649 Da. SH-oligopeptide-2: a shorter peptide fragment with IGF-1-like activity. Mechanism: IGF-1R (IGF-1 receptor) → IRS-1/IRS-2 phosphorylation → PI3K/Akt/mTOR (anabolism, protein synthesis) + MAPK/ERK (proliferation). In the skin: IGF-1R on fibroblasts, keratinocytes, melanocytes. Key difference from EGF: IGF-1 is more specific for dermal fibroblasts and metabolic processes (not just proliferation).

Anti-aging serums and creams for dermal restoration, products for mature skin with pronounced loss of elasticity, combinations with EGF analogues for synergistic effect.

Key Benefits

✦

IGF-1R activation — specific stimulation of fibroblasts

SH-Oligopeptide-2 activates IGF-1 receptors — predominantly expressed on dermal fibroblasts. Mechanism: IGF-1R → IRS-1 → PI3K → PIP3 → Akt → mTOR → S6K → stimulation of mRNA protein translation (including collagen, elastin). Advantage of the IGF-1R pathway vs EGFR: more focused on anabolic synthesis (not just proliferation) → deeper restoration of the dermal matrix without excessive cell division. In vitro: IGF-1 → increased synthesis of procollagen I and III by 80-120%. Clinical effect: denser and more elastic dermis with prolonged use.

◈

Synthesis of hyaluronic acid and elastin

SH-Oligopeptide-2 (IGF-1 analogue) stimulates not only collagen but also other key matrix components. Hyaluronic acid: IGF-1 activates HAS2 (hyaluronate synthase 2) in fibroblasts → increased HA synthesis → improved hydration and turgor of the dermis. Elastin: IGF-1 → increased transcription of ELN (elastin gene) → more elastic fibers. Proteoglycans (versican, decorin): IGF-1 increases their synthesis → better matrix structure. Practical effect: more plump, elastic, and hydrated skin with increased turgor — signs of youthful dermis.

✧

Synergy with EGF analogues — complex growth factor effect

SH-Oligopeptide-2 (IGF-1) and SH-Oligopeptide-1/SH-Polypeptide-1 (EGF) act through different receptors → synergy in complex formulations. EGF (EGFR) + IGF-1 (IGF-1R): partial synergy through common downstream effectors (Akt, MAPK) and mutual potentiation. Scientific basis: the combination of EGF + IGF-1 in wound healing shows better results than each separately. Practice: many premium K-beauty and Japanese anti-aging serums contain both peptides. Synergy also with: FGF analogues (SH-polypeptide-9), KGF analogues, growth factor cocktails.

Suitable for

mature skin with loss of elasticityflaccid and dehydrated skinskin after procedures

Main Actions

✓ IGF-1R activation of fibroblasts✓ synthesis of collagen, elastin, and hyaluronic acid✓ synergy with EGF for a comprehensive growth factor effect

SH-Oligopeptide-2: IGF-1 in cosmetics

SH-Oligopeptide-2 = IGF-1 analogue for topical application. Effective concentration: 0.001-0.01%. INCI: SH-Oligopeptide-2. Less studied than EGF analogues — fewer clinical studies specifically for cosmetics. Store at 2-8°C. Water-soluble, pH-stable 4-8. Like EGF analogues: consult a doctor in case of oncological diseases. Most effective in combination with EGF (SH-oligopeptide-1 or SH-polypeptide-1).

CategoryPeptides

Frequently Asked Questions

What does SH-Oligopeptide-2 do for skin?

Anti-aging serums and creams for dermal restoration, products for mature skin with pronounced loss of elasticity, combinations with EGF analogues for synergistic effect.

Who should use SH-Oligopeptide-2?

SH-Oligopeptide-2 is suitable for: mature skin with loss of elasticity, flaccid and dehydrated skin, skin after procedures.

Are there any warnings about SH-Oligopeptide-2?

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