Soothing

Panthenol Triacetate

Panthenol Triacetate — a lipophilic ester of provitamin B5 that penetrates the skin's lipid barrier better than regular panthenol. It provides soothing and regenerating effects with improved bioavailability in oil and silicone formulations.

provitamin B5lipophilic estersoothing actionbarrier regeneration

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Panthenol Triacetate (INCI: Panthenol Triacetate) — an ester of panthenol with three acetate groups replacing the hydroxyl groups of the original molecule. Mechanism: increased lipophilicity allows better incorporation into anhydrous and silicone formulations, where regular water-soluble panthenol poorly dissolves. In the skin, the ester bonds are gradually hydrolyzed by enzymes (esterases) to active pantothenic acid (vitamin B5), providing a slow but steady release of the active form.

Anhydrous and silicone formulations (balms, oil serums), sunscreens, soothing after-sun products, barrier repair agents in oil and balm formats.

Key Benefits

✦

Soothing and anti-inflammatory action

Panthenol triacetate, after hydrolysis to the active form of pantothenic acid, exhibits the classic soothing properties of vitamin B5 — reducing redness, irritation, and discomfort of the skin. Mechanism: pantothenic acid is a cofactor in the metabolic processes of cell regeneration and synthesis of coenzyme A, supporting cellular restorative potential. Particularly effective in anhydrous formulations (balms, oils), where water-soluble panthenol cannot be effectively incorporated.

◈

Improved bioavailability in lipophilic formulations

Unlike regular panthenol, panthenol triacetate dissolves well in the oil and silicone phase, allowing the incorporation of active B5 into formulations where the aqueous phase is absent or minimal. Mechanism: acetate groups mask the polarity of the hydroxyl groups of panthenol, making the molecule compatible with lipophilic environments. Result: expanded formulation possibilities — active vitamin B5 is now available in anhydrous balms, oil serums, and silicone bases for makeup.

✧

Support for skin barrier recovery

After hydrolysis to pantothenic acid, panthenol triacetate helps maintain the skin's barrier function by stimulating cellular metabolism and lipid synthesis in the stratum corneum. Result: reduced transepidermal water loss, accelerated recovery after irritation or barrier damage (e.g., after aggressive procedures or sun exposure). Often combined with: ceramides and other lipids in barrier repair formulations.

Suitable for

dry and irritated skinskin after sun exposureskin needing barrier recovery

Main Actions

✓ soothing and anti-inflammatory action✓ improved bioavailability in lipophilic formulations✓ support for barrier recovery

Panthenol Triacetate: difference from panthenol

Panthenol triacetate requires enzymatic hydrolysis for activation — the action unfolds more slowly than that of regular panthenol but lasts longer. INCI: Panthenol Triacetate. Concentration: 0.1-2% in anhydrous and silicone formulations. Safe and non-irritating, suitable for sensitive skin.

CategorySoothing Ingredients

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