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Peptide

Palmitoyl Tripeptide-8

Palmitoyl Tripeptide-8 — a lipopeptide with a unique anti-inflammatory mechanism through antagonism of the neuropeptide receptor. It soothes sensory irritation of the skin, reduces redness and hyperreactivity — an effective component for sensitive and reactive skin. Known as Neutrazen (Lipotec).

anti-inflammatorysensitive skinneuropeptideanti-redness
✓ Safe
Comedogenic Rating
0/5
Irritation Potential
0/5

What is it?

Palmitoyl Tripeptide-8 (INCI: Palmitoyl Tripeptide-8) — palmitoylated tripeptide (C16-Lys-Val-Lys or analog). MW: ~600 Da. Mechanism: antagonism of PAR-2 (protease-activated receptor 2) — a receptor activated by proteases during inflammation and irritation; inhibition of substance P and CGRP release (neuropeptides of pain and inflammation) → reduction of neurogenic inflammation. Result: decreased skin sensitivity to irritants, reduced redness. Palmitoyl group: increases lipophilicity and permeability through SC.

Products for sensitive, reactive, and hyperreactive skin, anti-redness and rosacea products, post-procedure care, anti-redness serums.

Key Benefits

✦
Neurogenic inflammation — a unique mechanism for sensitive skin
Palmitoyl tripeptide-8 (Neutrazen) addresses the neurogenic component of skin inflammation — often overlooked by traditional anti-inflammatory agents. Neurogenic inflammation: irritants activate C-fibers → release of substance P and CGRP → degranulation of mast cells → histamine, prostaglandins → redness, itching, swelling. Neutrazen blocks this cascade at early stages: inhibition of neuropeptide release. Clinical data: significant reduction in TEWL and redness during skin irritation (SDS test) compared to control.
◈
Reduction of hyperreactivity and sensory irritation
Skin with rosacea and sensitive skin are characterized by increased density of sensory nerves and hyperexpression of neuropeptide receptors. Palmitoyl tripeptide-8 reduces this hyperreactivity: decreased sensation of heat, tingling, itching upon contact with irritants. Effective in neurogenic rosacea (where neuropeptides play a role alongside vascular changes). Reduction of TEWL under stress — skin better maintains barrier function. Long-term effect: reduction of nerve ending sensitization with prolonged use.
✧
Synergy with other calming ingredients
Palmitoyl tripeptide-8 is effective in combined soothing systems. Synergy with: bisabolol (anti-inflammatory through COX/LOX inhibition) — different mechanisms; allantoin (protection and soothing of the epidermis); niacinamide (barrier support + vascular effects in rosacea); dipotassium glycyrrhizate (anti-inflammatory licorice pathway). No antagonism with most active ingredients. Ideal for post-laser, post-peel formulations: reduction of the neurogenic component of procedural inflammation.

Suitable for

sensitive and reactive skinskin with rosaceaskin after procedures

Main Actions

✓ inhibition of neurogenic inflammation✓ reduction of redness and hyperreactivity✓ soothing sensitive skin
Palmitoyl Tripeptide-8: Neutrazen and applications

Palmitoyl tripeptide-8 = Neutrazen (Lipotec/Lubrizol). Effective concentration: 1-3% Neutrazen systems (0.001-0.003% pure peptide). INCI: Palmitoyl Tripeptide-8. pH: stable 4-8. Water-soluble. Introduce in the cold phase (<40°C). Store at 2-8°C. Effect noticeable after 2-4 weeks of regular use. Synergy: particularly effective in combination with bisabolol and allantoin.

CategoryPeptides

Frequently Asked Questions

What does Palmitoyl Tripeptide-8 do for skin?
Products for sensitive, reactive, and hyperreactive skin, anti-redness and rosacea products, post-procedure care, anti-redness serums.
Who should use Palmitoyl Tripeptide-8?
Palmitoyl Tripeptide-8 is suitable for: sensitive and reactive skin, skin with rosacea, skin after procedures.
Are there any warnings about Palmitoyl Tripeptide-8?
Palmitoyl tripeptide-8 = Neutrazen (Lipotec/Lubrizol). Effective concentration: 1-3% Neutrazen systems (0.001-0.003% pure peptide). INCI: Palmitoyl Tripeptide-8. pH: stable 4-8. Water-soluble. Introduce in the cold phase (<40°C). Store at 2-8°C. Effect noticeable after 2-4 weeks

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