Peptide

Palmitoyl Tripeptide-38

MATRIXYL synthe'6 — the youngest peptide of the Matrixyl family activates the synthesis of six matrix components simultaneously: collagen I, III, IV, laminin-5, hyaluronic acid, and fibronectin. The most complex peptide stimulation in one molecule.

MATRIXYL synthe'66 matrix componentscollagenanti-aging

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Tripeptide-38 — palmitoyl ester of a tripeptide (KTTKS-derived, a new generation of Matrixyl). The trade name is MATRIXYL synthe'6® (Sederma/Croda). The name indicates six target matrix molecules: collagen I, III, IV, laminin-5, HA, and fibronectin. Each of these molecules plays a specific role: collagen I and III — elasticity and density, collagen IV and laminin-5 — basement membrane, HA — matrix hydration, fibronectin — cell adhesion.

Premium third-generation anti-aging formulas. The first generation — Matrixyl (PAL-KTTKS), the second — Matrixyl 3000 (PAL-GHK+PAL-GQPR), the third — MATRIXYL synthe'6. Effective concentration: 2–3 ppm.

Key Benefits

✦

Stimulation of 6 matrix components simultaneously

Unparalleled breadth: collagen I (+206%), collagen III (+49%), collagen IV (+190%), laminin-5 (+322%), hyaluronic acid (+80%), fibronectin (+153%) — data from Sederma in vitro. Each component plays its role in the structure and function of the skin. The effect encompasses both the dermis (collagens I/III) and the basement membrane (IV, laminin), and the matrix (HA, fibronectin).

◈

Clinical reduction of wrinkles and increased density

In vivo clinical study by Sederma: 3% cream with MATRIXYL synthe'6 vs placebo, 2 months — reduction in wrinkle volume by 27%, increased skin density. Results are better than for previous generations of Matrixyl under the same testing conditions.

✧

Restoration of the basement membrane — a unique action

Laminin-5 (+322%) and collagen IV (+190%) — components of the basement membrane between the epidermis and dermis. Stimulation of these structures restores the mechanical connection between skin layers — lifting, tightening, and counteracting sagging. A similar action is seen with acetyl tetrapeptide-9 and hexapeptide-11, but through a different mechanism.

Suitable for

mature skinskin with wrinklesnormal skin

Main Actions

✓ comprehensive matrix stimulation (6 components)✓ reduction of wrinkles✓ restoration of the basement membrane

Three generations of Matrixyl

Matrixyl 1 (PAL-KTTKS) — stimulates collagen I, HA. Matrixyl 3000 (PAL-GHK + PAL-GQPR) — adds anti-inflammatory action through tetrapeptide-7. MATRIXYL synthe'6 (palmitoyl tripeptide-38) — 6 matrix targets, including the basement membrane. Each generation has broader coverage. For maximum effect — a formula with two to three generations simultaneously.

CategoryPeptides

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