Peptide

Palmitoyl Tripeptide-3

Palmitoyl Tripeptide-3 — a lipopeptide with palmitic acid and a tripeptide that stimulates collagen synthesis through the activation of TGF-beta receptors. Clinically proven reduction in wrinkle depth and increased skin elasticity. Known as Syn-Coll (Pentapharm).

collagen synthesisTGF-betaanti-agingelasticity

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Tripeptide-3 (INCI: Palmitoyl Tripeptide-3) — palmitoylated tripeptide. MW: ~600-700 Da. Mechanism: the peptide part activates TGF-beta receptors → SMAD2/3 phosphorylation → activation of transcription of COL1A1, COL3A1 (collagen I and III). Palmitoyl-‘anchor’: increases lipophilicity → better penetration through the lipid layer of the SC → higher bioavailability than that of the pure peptide. Water-oil solubility due to the amphiphilic structure. TGF-beta-like effect without stimulating cell proliferation (safer profile).

Anti-aging serums and creams, wrinkle treatments, products for improving the elasticity of mature skin.

Key Benefits

✦

TGF-beta mimetic — stimulation of collagen synthesis

Palmitoyl tripeptide-3 is a functional mimetic of TGF-beta — stimulates the same post-receptor pathways without excessive proliferative activity of TGF-beta. Mechanism: binding to TGF-beta receptor II → activation of SMAD2/3 → increased transcription of COL1A1 and COL3A1. In vitro: increased pro-collagen I synthesis by 119% at 1 µM. The effect persists long after discontinuation (long-term stimulation of matrix remodeling). Less toxic than TGF-beta itself (does not stimulate excessive fibrosis).

◈

Clinically proven wrinkle reduction (Syn-Coll)

Clinical data from Pentapharm/DSM for Syn-Coll (palmitoyl tripeptide-3): 12-week application of 3% Syn-Coll — silicone replica analysis: reduction of average wrinkle depth by 27%, reduction of maximum depth by 23%. Expert grading: improvement in overall skin appearance (statistically significant vs placebo). Self-assessment: 78% of participants noted improvement. The effect is comparable to palmitoyl pentapeptide-4 (Matrixyl) with a more specific mechanism of action.

✧

Synergy in complex anti-aging formulas

Palmitoyl tripeptide-3 is synergistic with other peptides and actives. Combination with palmitoyl pentapeptide-4 (Matrixyl): synergy of TGF-beta + matrix-competent pathway. With acetyl hexapeptide-3 (Argireline): collagen + muscle relaxation. With retinol: enhancement of ECM stimulation through different mechanisms. Not antagonistic with most cosmetic actives. Stable in formulas with hyaluronic acid, niacinamide, vitamin C derivatives.

Suitable for

mature skinskin with wrinklessagging skin

Main Actions

✓ TGF-beta-like stimulation of collagen✓ clinical reduction of wrinkles✓ increased skin elasticity

Palmitoyl Tripeptide-3: Syn-Coll and concentrations

Palmitoyl tripeptide-3 = Syn-Coll (Pentapharm/DSM). Effective concentration: 1-3% of the finished Syn-Coll system (0.001-0.003% of pure peptide). INCI: Palmitoyl Tripeptide-3. Stable at pH 4-8, water-soluble. Introduce in the cold phase. Synergy: Syn-Coll + Matrixyl 3000 = Matrixyl Synthe 6 (commercial system). Store at 2-8°C.

CategoryPeptides

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