Peptide

Palmitoyl Tetrapeptide-7

Lipopetide that mimics the effect of the natural immunomodulator thymosin β4 — reduces interleukin-6 levels (marker of inflammation and skin aging). Reduces chronic inflammation underlying photoaging and is the basis of the Matrixyl 3000 complex.

lipopetideanti-inflammatory peptideMatrixyl 3000anti-inflammaging

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Tetrapeptide-7 — lipopetide: palmitic acid (C16) + tetrapeptide Gly-Gln-Pro-Arg. Molecular weight ~758 Da. Water-soluble (ionic form). Developed by Sederma (now Croda). Trade complex: Matrixyl 3000 = Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7. Mechanism of action: the peptide sequence GQPR mimics a fragment of thymosin β4 and growth factor IGF-1 → signals cells to suppress pro-inflammatory cytokines. Clinically confirmed effect on reducing IL-6 and MMP (matrix metalloproteinases).

Anti-aging serums and creams (especially Matrixyl 3000 systems), products for mature and sensitive skin, means against photoaging and chronic inflammation.

Key Benefits

✦

Reduction of inflammaging — chronic inflammation that accelerates aging

Inflammaging — chronic subclinical inflammation that is a key mechanism of skin aging. IL-6, TNF-α, and other cytokines stimulate MMP (metalloproteinases) that break down collagen and elastin. Palmitoyl Tetrapeptide-7 clinically reduces IL-6 by 27% in skin cell cultures. Reduction of IL-6 → decrease in MMP activity → preservation of collagen → fewer wrinkles. Especially important for photo-damaged skin and skin 40+.

◈

Synergy in Matrixyl 3000 — dual peptide action

Palmitoyl Tetrapeptide-7 was developed as a complement to Palmitoyl Tripeptide-1 in the Matrixyl 3000 system: PT-1 stimulates the synthesis of new structural proteins (collagen I, III, IV, fibronectin), PT-7 simultaneously reduces their degradation by MMP. Sederma study: Matrixyl 3000 (0.02% of each peptide) in a 12-week clinical study reduced wrinkle volume by 45% compared to placebo.

✧

Soothing effect for reactive skin

Due to the anti-inflammatory mechanism, Palmitoyl Tetrapeptide-7 is effective in products for sensitive and reactive skin: reduces redness after aggressive procedures (acid peels, laser treatments), soothes skin in cases of rosacea. An unusual advantage — combines anti-aging (anti-inflammaging) and soothing action in one molecule.

Suitable for

mature skin 35+sensitive and reactive skinafter aggressive procedures

Main Actions

✓ reduction of IL-6 and inflammaging✓ protection of collagen from MMP✓ soothing action

Matrixyl 3000: optimal concentration

Matrixyl 3000 (Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7): clinically effective concentration of each peptide — 0.005–0.02% in the finished product. Sederma recommends: 2–4% concentrate of Matrixyl 3000 in the product (in the concentrate ~0.5% of each peptide). Check the composition: if Palmitoyl Tetrapeptide-7 is listed before preservatives — the concentration is likely sufficient for effectiveness.

CategoryPeptides

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