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Peptide

Palmitoyl Oligopeptide

The classic collagen precursor peptide — palmitoyl oligopeptide stimulates the synthesis of collagen and HA through a sequence that mimics the natural matrixins of the skin. It is often found in combination with palmitoyl tetrapeptide-7 in anti-aging formulas.

collagenanti-agingpeptidematrix
✓ Safe
Comedogenic Rating
0/5
Irritation Potential
0/5

What is it?

Palmitoyl Oligopeptide — a collective INCI name for palmitoylated peptide chains (usually 3–9 amino acids). In cosmetics, it most often refers to fragments of type I collagen or their synthetic analogs with an attached palmitoyl "anchor." Increased lipophilicity promotes penetration through the lipid barrier of the stratum corneum. It activates TGF-β and procollagen synthesis in fibroblasts.

An anti-aging component in combination with other peptides — especially often with palmitoyl tetrapeptide-7. Effective in night creams and serums for mature skin at concentrations of 1–3 ppm.

Key Benefits

✦
Stimulation of collagen I and hyaluronic acid synthesis
The oligopeptide fragment is recognized by fibroblast receptors as a signal of matrix degradation — triggering the synthesis of new collagen. Synthesis of HA and fibronectin is also increased. The effect is similar to palmitoyl pentapeptide-4 (Matrixyl), but with a slightly different peptide sequence.
◈
Increased density and elasticity of the skin
Regular use increases collagen content in the dermis, expressed in increased density and elasticity. Reduction of lines and fine wrinkles is noticeable after a 6–8 week course. The best effect is achieved in combination with antioxidants (vitamin C, E) and moisturizers.
✧
Complex with Palmitoyl Tetrapeptide-7
The popular combination of palmitoyl oligopeptide + palmitoyl tetrapeptide-7 simultaneously affects matrix synthesis and inflammation. Tetrapeptide-7 reduces IL-6 and interleukin inflammation — together the pair overlaps two mechanisms of aging changes.

Suitable for

mature skinnormal skinskin with wrinkles

Main Actions

✓ stimulation of collagen✓ increase in elasticity✓ strengthening the matrix
Palmitoyl Oligopeptide vs Pentapeptide-4

Both are palmitoyl peptides-matrixins, but with different sequences. Pentapeptide-4 (KTTKS) — Matrixyl original, the most clinically studied. Oligopeptide — a broader term, often used as a cheaper alternative in complex peptide formulas. When choosing a product — check the specific sequence or the presence of the trade name Matrixyl.

CategoryPeptides

Frequently Asked Questions

What does Palmitoyl Oligopeptide do for skin?
An anti-aging component in combination with other peptides — especially often with palmitoyl tetrapeptide-7. Effective in night creams and serums for mature skin at concentrations of 1–3 ppm.
Who should use Palmitoyl Oligopeptide?
Palmitoyl Oligopeptide is suitable for: mature skin, normal skin, skin with wrinkles.
Are there any warnings about Palmitoyl Oligopeptide?
Both are palmitoyl peptides-matrixins, but with different sequences. Pentapeptide-4 (KTTKS) — Matrixyl original, the most clinically studied. Oligopeptide — a broader term, often used as a cheaper alternative in complex peptide formulas. When choosing a product — check the specif

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