Antioxidant

Nicotinamide Riboside

Nicotinamide Riboside — a precursor of NAD+ (nicotinamide adenine dinucleotide), a key coenzyme in cellular metabolism and energy exchange. In cosmetics, it is used to support cellular energy and anti-aging protection of the skin at the molecular level.

precursor of NAD+cellular energyanti-agingmolecular support of metabolism

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Nicotinamide Riboside (INCI: Nicotinamide Riboside) — a nucleoside that is metabolized in cells through the enzyme NRK (nicotinamide riboside kinase) directly into NAD+, bypassing some steps required for conversion from niacinamide. Mechanism: the level of NAD+ in cells naturally decreases with age and under oxidative stress, correlating with a decrease in cellular energy and DNA repair capacity. Supplementing NAD+ through nicotinamide riboside theoretically supports the energy metabolism of keratinocytes and fibroblasts, contributing to better functioning of cellular repair mechanisms.

Premium anti-aging serums and creams, formulas focusing on cellular health and skin longevity, products for mature skin with reduced regenerative capacity.

Key Benefits

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Support for cellular NAD+ levels and energy metabolism

Nicotinamide riboside effectively increases intracellular NAD+ levels — a coenzyme necessary for the functioning of hundreds of enzymatic reactions, including cellular energy production (ATP) in mitochondria. Mechanism: direct conversion to NAD+ through a pathway that is partially independent of the traditional niacinamide pathway. Result: theoretical support for the energy potential of skin cells, which is especially relevant for mature skin with slowed cellular metabolism.

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Support for DNA repair mechanisms

NAD+ serves as a necessary substrate for the sirtuin (SIRT) and PARP (poly-ADP-ribose polymerase) family of enzymes involved in DNA repair mechanisms and regulation of cellular aging. Mechanism: maintaining sufficient levels of NAD+ through nicotinamide riboside theoretically supports the activity of these protective enzymes, contributing to better resistance of skin cells to the accumulation of DNA damage related to UV exposure and age-related changes.

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Anti-aging support at the molecular level

Due to its role in fundamental cellular processes, nicotinamide riboside is positioned as a next-generation ingredient in anti-aging cosmetics that works at the level of cellular metabolism, rather than just addressing surface symptoms of aging. Often combined with: other NAD+ precursors (NMN) and antioxidants for comprehensive support of cellular health in premium formulas.

Suitable for

mature skinskin with signs of cellular aging

Main Actions

✓ increasing cellular NAD+ levels✓ supporting DNA repair✓ supporting cellular energy

Nicotinamide Riboside: novelty and research

Nicotinamide riboside — a relatively new cosmetic ingredient that initially gained major attention in nutraceuticals (dietary supplements to support NAD+); topical studies on skin are still limited compared to the well-studied niacinamide. INCI: Nicotinamide Riboside. Concentration: 0.1-2% in premium formulas.

CategoryAntioxidants

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