Humectant

Hydrolyzed Sodium Hyaluronate

Fragmented low molecular weight hyaluronic acid - penetrates significantly deeper than standard hyaluronate. Reaches the living layers of the epidermis, where it stimulates the body's own synthesis of HA and enhances hydration from within.

low molecular weight HAdeep penetrationhydration of the dermisstimulation of HA

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Hydrolyzed Sodium Hyaluronate - sodium salt of hyaluronic acid, depolymerized to a molecular weight of <10 kDa (oligohyaluronate) or <5 kDa. Obtained by enzymatic (hyaluronidase) or chemical hydrolysis of standard Sodium Hyaluronate. Small MW → capable of penetrating through the stratum corneum (SC) to the epidermis and upper dermis. Unlike standard HA (MW ~1-2 MDa, remains on the surface) and cross-linked HA (remains in SC). Can interact with CD44 receptors on keratinocytes and fibroblasts → stimulates the body's own synthesis of HA.

Premium serums with HA of multi-molecular spectrum, anti-aging products for mature skin, ampoule concentrates for deep hydration, complex HA formulas.

Key Benefits

✦

Penetration into deep layers - hydration from within

Standard Sodium Hyaluronate (MW ~1 MDa) forms a moisturizing film on the skin's surface - excellent effect, but limited by the stratum corneum. Hydrolyzed Sodium Hyaluronate (MW <10 kDa) penetrates through SC to the living cells of the epidermis. Fluorescent labeling studies: HA fragments <5 kDa are found in the granular and spiny layers 24 hours after application. Deeper hydration → more stable moisture retention.

◈

Stimulation of the body's own synthesis of hyaluronic acid

Small HA fragments interact with CD44 receptors on keratinocytes and fibroblasts as signaling molecules: activate HAS1, HAS2 genes (hyaluronate synthase) → cells increase their own production of HA. This fundamentally distinguishes hydrolyzed HA from a regular moisturizer: it not only 'fills' moisture reserves but enhances the skin's ability to retain it. The effect persists after discontinuation of the product.

✧

Synergy with other forms of HA - multi-molecular HA

The most effective application - in combination with different molecular weights of HA: high MW (film-forming on the surface) + mid MW (SC hydration) + hydrolyzed low MW (deep penetration). Premium HA serums usually contain 3+ forms of HA. If you see 'Sodium Hyaluronate' + 'Hydrolyzed Sodium Hyaluronate' + 'Sodium Hyaluronate Crosspolymer' - these are three different levels of hydration covering the entire spectrum.

Suitable for

mature skindehydrated skindeep hydration

Main Actions

✓ deep hydration of the epidermis✓ stimulation of the body's own synthesis of HA✓ multi-molecular HA synergy

Molecular weights of HA - what penetrates where

High MW HA (>500 kDa): remains on the surface, film-forming, instant smoothing. Mid MW HA (50–500 kDa): penetrates the stratum corneum, long-lasting hydration of SC. Low MW / Hydrolyzed HA (<10 kDa): living epidermis + upper dermis. Ultra-low (oligomeric <5 kDa): deepest penetration, strongest stimulation of CD44. Sodium Hyaluronate Crosspolymer: retained in SC, long-lasting moisture depot. Each form has a unique niche - maximum effect when combined.

CategoryHumectants

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