Flavonoid
Fisetin
A potent strawberry-derived flavonol with strong antioxidant and senolytic properties — emerging as one of the most promising longevity-focused skincare ingredients.
AntioxidantAnti-AgingSenolyticFlavonoid
⚠ Unknown
Comedogenic Rating
0/5
Irritation Potential
0/5
What is it?
A strawberry-derived flavonol with both potent antioxidant and senolytic (senescent cell-clearing) activity in skin.
Reduces the accumulation of senescent cells in aging skin, provides powerful antioxidant protection, and addresses a fundamental driver of skin aging.
Key Benefits
Senolytic Activity
Selectively clears senescent cells from skin tissue, reducing SASP-driven chronic inflammation and improving skin renewal capacity.
Potent Antioxidant
Among the strongest antioxidants in the flavonoid class — outperforms quercetin, kaempferol, and myricetin in several models.
Collagen Protection
Inhibits MMP enzymes that degrade collagen and elastin, preserving skin structure.
Anti-Inflammatory
Reduces NF-kB-driven inflammation, particularly the SASP inflammatory factors released by senescent cells.
Suitable for
Main Actions
Formulation Note
Fisetin is poorly soluble in water and requires lipid-based or encapsulated delivery systems for effective topical use. It pairs well with resveratrol and quercetin for synergistic anti-aging effects.
Frequently Asked Questions
What does Fisetin do for skin?
Reduces the accumulation of senescent cells in aging skin, provides powerful antioxidant protection, and addresses a fundamental driver of skin aging.
Who should use Fisetin?
Fisetin is suitable for: Mature skin, Sun-damaged skin, Skin with dullness and uneven texture, Anti-aging routines.
Are there any warnings about Fisetin?
Fisetin is poorly soluble in water and requires lipid-based or encapsulated delivery systems for effective topical use. It pairs well with resveratrol and quercetin for synergistic anti-aging effects.
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