Peptide

Dipeptide-2

Dipeptide-2 (Val-Trp) — a specific dipeptide that is an active inhibitor of ACE (angiotensin-converting enzyme). It reduces puffiness under the eyes, improves microcirculation and lymphatic drainage — a key ingredient in products against puffiness and dark circles.

ACE inhibitorpuffiness under the eyeslymphatic drainagemicrocirculation

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Dipeptide-2 (INCI: Dipeptide-2) — dipeptide L-valyl-L-tryptophan (H-Val-Trp-OH). MW: 317.4 Da. Mechanism: inhibition of angiotensin-converting enzyme (ACE) → dilation of small vessels → improved microcirculation; increased activity of lipoprotein lipase in the vessel wall → better fluid drainage; stimulation of lymphatic drainage → reduction of fluid accumulation under the eyes. Part of Eyeliss (Sederma): dipeptide-2 + hesperidin methyl chalcone + palmitoyl tetrapeptide-7 — a clinically studied system for puffiness and dark circles.

Eye area products against puffiness and dark circles, anti-puffiness serums, eye patches, premium eye creams.

Key Benefits

✦

ACE inhibition — reduction of puffiness under the eyes

Dipeptide-2 is a powerful ACE inhibitor — an enzyme involved in regulating vascular tone and fluid accumulation in tissues. Mechanism: inhibition of ACE → vasodilation of microvessels → improved drainage of fluid from periorbital tissues. Clinical data from Eyeliss (1% in the formula): 28-day application — 65% reduction in puffiness compared to placebo in a clinical study by Sederma. Reduction of "bags" under the eyes — mechanically verified improvement.

◈

Lymphatic drainage and microcirculation

Additional mechanism of dipeptide-2: stimulation of lymphatic capillaries in the periorbital area → drainage of accumulated fluid. Improvement of microcirculation: overcoming stasis (blood stagnation) in periorbital tissues. Result: reduction of dark circles due to improved tissue oxygenation (less pronounced bluish pigmentation from deoxygenated blood). Complementary action with hesperidin methyl chalcone in the Eyeliss system: synergy of lymphatic drainage + microcirculation.

✧

Eyeliss complex — a clinically studied system for the eyes

Dipeptide-2 is most effective as a component of the Eyeliss system (Sederma/Croda): Dipeptide-2 (0.5-1%) + hesperidin methyl chalcone + palmitoyl tetrapeptide-7. Clinical data from Eyeliss (Sederma): >20 clinical studies, results — reduction of puffiness, dark circles, improvement of skin elasticity around the eyes. Found in many premium eye creams and serums from well-known brands. Safety: good tolerance, suitable for the sensitive eye area.

Suitable for

eye areaskin prone to puffinessmature skin

Main Actions

✓ reduction of puffiness through ACE inhibition✓ lymphatic drainage and microcirculation✓ reduction of dark circles

Dipeptide-2: recommended system and concentration

Dipeptide-2 is most effective in the Eyeliss system (together with hesperidin methyl chalcone). Separately: 0.5-1% in the formula. In the Eyeliss system: 1-3% of the finished system (containing ~0.3-0.5% dipeptide-2). INCI: Dipeptide-2. pH stability: 4-8. Water-soluble. Synergy with caffeine (mechanical vessel constriction) + dipeptide-2 (drainage) = comprehensive effect against puffiness. Store at 4-25°C, avoid UV.

CategoryPeptides

Frequently Asked Questions

What does Dipeptide-2 do for skin?

Eye area products against puffiness and dark circles, anti-puffiness serums, eye patches, premium eye creams.

Who should use Dipeptide-2?

Dipeptide-2 is suitable for: eye area, skin prone to puffiness, mature skin.

Are there any warnings about Dipeptide-2?

Check if this ingredient works for your skin — analyze your full product formula for free.

Analyze your product