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Dimethyl Sulfone

Organic sulfur compound (MSM) — a natural source of bioavailable sulfur for the synthesis of keratin, collagen, and glutathione. In cosmetics, it supports the structural integrity of the skin, has anti-inflammatory and antioxidant effects. Known in nutraceuticals as MSM.

organic sulfurMSManti-inflammatorycollagen support

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Dimethyl Sulfone (INCI: Dimethyl Sulfone, also MSM = methylsulfonylmethane) — (CH₃)₂SO₂. Molecular weight ~94 Da. Well soluble in water. Natural source: product of DMSO (dimethyl sulfoxide) oxidation in the atmosphere. In the body: source of organic sulfur for synthesis: cysteine → keratin, collagen, glutathione, taurine. Mechanisms of action in cosmetics: 1) Supply of sulfur for keratin → strengthening hair and nails; 2) Anti-inflammatory activity (inhibition of NF-κB); 3) Antioxidant (precursor of glutathione); 4) Improvement of cell membrane permeability.

Products for strengthening and hair growth, nail strengthening products, anti-inflammatory creams and masks, anti-aging formulas supporting collagen synthesis.

Key Benefits

✦

Source of organic sulfur — strengthening keratin and collagen

Sulfur is a key element of disulfide bonds in keratin (S-S bridges between chains → mechanical strength of hair and nails) and in collagen (stabilization of structure). Dimethyl sulfone is the most bioavailable form of organic sulfur for cosmetic use. Topical application in hair products: strengthening the hair shaft, reducing brittleness. Synergy with cysteine, methionine, and biotin.

◈

Anti-inflammatory and antioxidant action

MSM (dimethyl sulfone) inhibits NF-κB and reduces levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α). Antioxidant effect: through increased intracellular levels of glutathione (GSH) → stronger protection against ROS. Clinical studies of oral MSM intake: reduction of joint inflammation. Topically: reduction of redness and irritation in inflammatory skin diseases (rosacea, dermatitis).

✧

Improvement of skin health and elasticity

Studies on topical application of MSM (16-week RCT): significant improvement in skin elasticity, reduction of wrinkle depth, and improvement of texture compared to placebo. Mechanism: sulfur → synthesis of new collagen and elastin → denser dermis. Additionally: improvement of barrier function through support of keratin in the stratum corneum.

Suitable for

brittle hairmature skininflamed skin

Main Actions

✓ supply of sulfur for keratin and collagen✓ anti-inflammatory and antioxidant effect✓ strengthening the structure of skin and hair

MSM: orally vs topically

Orally (MSM supplements): well-researched, effects on joints and hair confirmed. Topically: less evidence base, but there are RCTs with positive results. In cosmetics INCI: 'Dimethyl Sulfone' (not 'MSM'). Concentrations in topical formulas: 1–5%. Stable, does not oxidize. Well soluble in water and alcohol. Odorless in pure form (unlike DMSO). Suitable for vegan formulas.

Frequently Asked Questions

What does Dimethyl Sulfone do for skin?

Products for strengthening and hair growth, nail strengthening products, anti-inflammatory creams and masks, anti-aging formulas supporting collagen synthesis.

Who should use Dimethyl Sulfone?

Dimethyl Sulfone is suitable for: brittle hair, mature skin, inflamed skin.

Are there any warnings about Dimethyl Sulfone?

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