Barrier

Ceramides

The structural lipid of the skin — ceramides make up 50% of the lipids in the stratum corneum and are the foundation of the protective barrier. Without sufficient ceramides, the skin becomes dry, sensitive, and prone to inflammation. Restoring ceramides is the basis for treating atopic dermatitis.

barrierlipidshydrationatopic skin

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Ceramides are a class of sphingolipids composed of a fatty acid and sphingosine (or phytosphingosine). There are 12 subclasses in the skin (Ceramide NP, AP, EOP, NS, AS, EOS, etc.). Together with cholesterol and free fatty acids, they form lamellar bodies — a liquid crystalline structure between corneocytes. In cosmetics, either skin-identical (Ceramide NP, AP, EOP) or synthetic analogs are used. Some sources include wheat, soy, and rice bran.

A key component of formulations for barrier restoration: atopic skin, dry skin, post-procedure. Most effective in combination with cholesterol and fatty acids in a ratio of 1:1:1 (CeraVe formulation principle).

Key Benefits

✦

Lipid barrier restoration and reduction of TEWL

Topical ceramides integrate into the lamellar structure of the stratum corneum, "closing" the gaps between corneocytes. Clinical studies of CeraVe show a reduction in TEWL by 35–45% after 4 weeks of regular use. Basic therapy for atopic dermatitis and xerosis.

◈

Protection from external aggressors and microbes

An intact lipid barrier prevents the penetration of allergens, pollutants, and pathogens (C. acnes, S. aureus). In atopic dermatitis, the level of ceramides is reduced by 40–60% — restoring the barrier with ceramide-containing products significantly reduces the frequency of flare-ups.

✧

Reduction of sensitivity and soothing of the skin

A restored barrier reduces the skin's reactivity to irritants and temperature changes. Sensations of tightness, itching, and hypersensitivity decrease. The effect is especially pronounced when combined with panthenol and niacinamide.

Suitable for

atopic skindry skinsensitive skinmature skin

Main Actions

✓ barrier restoration✓ reduction of TEWL✓ protection from irritants

Not all ceramides are the same

Ceramide NP (formerly Ceramide 3) — the most researched; included in CeraVe, La Roche-Posay. Ceramide EOP — unique, contains linoleic acid, critically important for barrier structure. Phytosphingosine and sphingosine — precursors of ceramides, also effective. The best effect is achieved when combining several types.

CategoryBarrier Repair

From our blog

Best Skincare Ingredients for Dry Skin (And What to Avoid)Best Skincare Ingredients for Sensitive Skin (And What to Avoid)Ceramides & the Skin Barrier: Why It Breaks Down and How to Fix It How to Build a Skincare Routine: The Right Order for Every Step How to Layer Skincare Products: Order, Timing, and What Not to Mix Hyaluronic Acid: How It Works, Who Needs It & How to Apply It Hyaluronic Acid vs Glycerin: Which Humectant Is Right for You?Niacinamide: Complete Guide to Benefits, Uses & How to Layer It Peptides in Skincare: What They Do and Which Ones Actually Work Retinol: The Complete Beginner's Guide (How to Start Without Irritation)

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