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Asiaticoside

One of the four key active ingredients of Centella asiatica — asiaticoside stimulates collagen synthesis through a unique mechanism of activating the antimicrobial peptide LL-37, accelerates wound healing, and enhances the effect of madecassoside in skin recovery.

CentellaCollagenRecoveryHealing
✓ Safe
Comedogenic Rating
0/5
Irritation Potential
0/5

What is it?

Asiaticoside — a triterpenoid saponin isolated from Centella asiatica. One of the four main actives of Centella along with madecassoside, asiatic acid, and madecassic acid. Unlike madecassoside (which inhibits inflammation via NF-κB), asiaticoside acts primarily through the stimulation of the antimicrobial peptide LL-37 synthesis in keratinocytes. LL-37 is a catalyst for collagen synthesis via a TGF-β1-independent pathway. Additionally: asiaticoside is hydrolyzed in the skin to asiatic acid, which directly activates fibroblast proliferation. Clinically used in the Madecassol preparation for the treatment of wounds, burns, and scars — often in combination with madecassoside.

Products for recovery after procedures, scar treatment, soothing reactive skin. Synergistically used together with madecassoside, panthenol, and ceramides. Concentration 0.1–1% in combination with other actives of Centella. Predominantly found in standardized CICA formulas.

Key Benefits

✦
Stimulation of collagen through LL-37
Asiaticoside induces the synthesis of the antimicrobial peptide LL-37 in keratinocytes. LL-37 activates EGF (epidermal growth factor) receptors and initiates a cascade of collagen type I and III synthesis through a TGF-β1-independent pathway. This mechanism is complementary to madecassoside (which acts through TGF-β1), explaining the powerful effect of combining both molecules in CICA formulas.
◈
Wound healing and scar reduction
Clinical data confirm the effectiveness of asiaticoside in treating second-degree wounds, surgical incisions, and hypertrophic scars. The Madecassol preparation (asiaticoside + madecassic acid + asiatic acid) is used in medicine for the treatment of chronic wounds and burns. In vitro: accelerates keratinocyte migration and fibroblast proliferation, which are key stages of healing.

Suitable for

Sensitive and reactive skinSkin after proceduresSkin prone to scarring

Main Actions

✓ Stimulation of collagen synthesis✓ Acceleration of healing
CICA formulas: a combination of Centella actives

Most modern CICA products contain a combination of several Centella actives: madecassoside + asiaticoside + asiatic acid + madecassic acid. Together they provide a synergistic effect through various mechanisms (NF-κB, TGF-β1, LL-37, EGF). The standardized extract TECA (Titrated Extract of Centella Asiatica) contains 40% asiaticoside, 29–30% asiatic acid, 29–30% madecassic acid, and 1% madecassoside — the gold standard of clinical research.

CategorySoothing Ingredients

Frequently Asked Questions

What does Asiaticoside do for skin?
Products for recovery after procedures, scar treatment, soothing reactive skin. Synergistically used together with madecassoside, panthenol, and ceramides. Concentration 0.1–1% in combination with other actives of Centella. Predominantly found in standardized CICA formulas.
Who should use Asiaticoside?
Asiaticoside is suitable for: Sensitive and reactive skin, Skin after procedures, Skin prone to scarring.
Are there any warnings about Asiaticoside?
Most modern CICA products contain a combination of several Centella actives: madecassoside + asiaticoside + asiatic acid + madecassic acid. Together they provide a synergistic effect through various mechanisms (NF-κB, TGF-β1, LL-37, EGF). The standardized extract TECA (Titrated E

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