Emollient

Acetyl Tetrapeptide-2

Thymulen4 — thymus peptide that restores the immune function of the skin. It stimulates thymosin-α1 receptors, restores Langerhans dendritic cells, and supports a healthy stress response. Particularly effective for photo-aged and immunosuppressed skin.

Thymulen4thymus peptideskin immunityanti-aging

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Thymosin α-1 — a natural thymus hormone that regulates the differentiation and activity of T-lymphocytes and Langerhans cells (skin dendritic cells). The level of Tα1 decreases with age. Acetyl Tetrapeptide-2 is a shortened acetylated analog of Tα1 that retains its receptor activity. Langerhans cells are the skin's "guard": they respond to UV, pathogens, and irritants. When they are depleted (stress, UV, age) — skin immunity is reduced. INCI: Acetyl Tetrapeptide-2. Effective concentration: 3–5 ppm.

Anti-aging and anti-stress formulas. Particularly valuable in combinations with UV filters (restoration after UV immunosuppression) and peptides for mature skin.

Key Benefits

✦

Restoration of Langerhans cells — the "immunity" of the skin

UV radiation and chronic stress deplete the population of Langerhans cells — dendritic cells of the dermis. A decrease in their number = weakened skin immunity, slow regeneration, increased reactivity. Acetyl Tetrapeptide-2 stimulates the restoration of functional Langerhans cells → increased immune protection and normalization of inflammatory reactions.

◈

Increased collagen synthesis through the neuroimmune pathway

Langerhans cells regulate fibroblast activity through neuroimmune signals. Restoration of their population → restoration of normal regulation of collagen and elastin synthesis. Lipotec research: 3 ppm Thymulen4 — statistically significant increase in procollagen I synthesis in fibroblast cultures.

✧

Protection against UV-induced immunosuppression

UV is the largest factor of skin immunosuppression. Thymulen4 protects and restores Langerhans cells after UV exposure, compensating for one of the key mechanisms of photoaging. Recommended in post-sun formulas and in day creams along with UV filters for comprehensive protection.

Suitable for

mature skinskin after sun exposurereactive skinskin with weakened protection

Main Actions

✓ restoration of Langerhans cells✓ stimulation of collagen synthesis✓ protection against UV immunosuppression

Neuroimmunology in cosmetology

The skin has its own neuroimmune system — a network of Langerhans cells, mast cells, and nerve fibers. This system regulates inflammation, regeneration, and aging. Thymulen4 (Acetyl Tetrapeptide-2) is one of the first cosmetic ingredients that specifically targets this system. The combination with neuropeptides (Calmosensine, Argireline) provides a comprehensive neurocosmetic effect.

CategoryEmollients

Check if this ingredient works for your skin — analyze your full product formula for free.

Analyze your product