Emollient

Acetyl Octapeptide-3

SNAP-8 — an advanced analogue of Argireline with a peptide twice as long. Acetyl octapeptide-3 more effectively blocks neuromuscular transmission and reduces expression wrinkles. It is used where a stronger effect is needed than that of acetyl hexapeptide-3.

SNAP-8muscle relaxantexpression wrinklesneuropeptide

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Acetyl Octapeptide-3 — an acetylated octapeptide, trade name SNAP-8® (Lipotec). It is an extended version of SNAP-25 mimetic compared to acetyl hexapeptide-3 (Argireline). Peptide sequence: EEMQRRAD — covers a larger fragment of SNAP-25 than Argireline (6 amino acids). It competitively inhibits the SNARE complex, preventing the fusion of vesicles with the neurotransmitter with the membrane — the contraction signal transmission does not occur.

Used in the same products as Argireline, but in more concentrated or premium formulas. Effective concentration 5–10%. Especially effective around the eyes and forehead.

Key Benefits

✦

Stronger blockade of SNAP-25 — up to 63% reduction in contractions

The octapeptide covers a larger fragment of SNAP-25 than the hexapeptide — competitive inhibition is more effective. Lipotec studies: SNAP-8 5% reduces wrinkle depth by 63% more than placebo, compared to 35% for Argireline. The 'topical botox' effect is more pronounced.

◈

Reduction of expression wrinkles around the eyes and forehead

Targeted action on areas of maximum expression activity — "crow's feet," frown lines (11-wrinkles), horizontal forehead lines. Clinical studies ex vivo on skin: after 28 days — statistically significant reduction in depth and length of wrinkles compared to control.

✧

Synergy with Argireline and other neuropeptides

Some premium formulas combine SNAP-8 + Argireline for maximum SNAP-25 blockade. Effectively combined with leuphasyl (5 amino acids, different mechanism: through enkephalin receptors) — different points of application provide an additional effect.

Suitable for

mature skinskin with expression wrinklesnormal skin

Main Actions

✓ blockade of expression wrinkles✓ neuromuscular muscle relaxant✓ smoothing of expression lines

SNAP-8 vs Argireline: which is more powerful?

Argireline (acetyl hexapeptide-3) — 6 amino acids, basic level of blockade. SNAP-8 (acetyl octapeptide-3) — 8 amino acids, stronger competition for the binding site of SNAP-25. SNAP-8 is more effective at the same concentrations. But both are non-toxic, without muscle paralysis, the effect is reversible and depends on the regularity of application.

CategoryEmollients

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