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Acetyl Hexapeptide-3

Neuropeptide known as Argireline® — "botox in a bottle" without injections. It blocks the release of neurotransmitters at neuromuscular synapses, reducing the intensity of facial muscle contractions and smoothing out expressive wrinkles. A safe alternative to botulinum toxin for topical use.

neuropeptideArgirelinemyorelaxing effectanti-aging

⚠ Use with Caution

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Acetyl Hexapeptide-3 competitively inhibits the SNARE complex: it binds to SNAP-25 and syntaxin, blocking the exocytosis of acetylcholine at synapses. Result: reduced amplitude of facial muscle contractions → less deep facial expressions → smoothing of dynamic wrinkles. Difference from botox (botulinum toxin): does not completely block but reduces intensity → natural expression is preserved. Molecular weight ~888 Da — relatively large for a peptide. Palmitoyl analog (Acetyl Hexapeptide-8 = Argireline Amplified): additional palmitic acid for deeper penetration; both variants may appear in INCI. Concentration in products: 5–10%.

Anti-wrinkle serums for facial mimicry, products for the skin around the eyes and lips, "express lifting" serums, daytime care for the prevention of mimic wrinkles.

Key Benefits

✦

Reduction of mimic wrinkles — clinical data

Clinical study by Lipotec (10% acetyl hexapeptide-3, 30 days): reduction of wrinkle depth on the forehead and around the eyes by 17–27% compared to placebo. The effect is cumulative: maximum result — 4–8 weeks of regular use. Areas: horizontal forehead wrinkles, "crow's feet", wrinkles above the bridge of the nose (glabellar — "eleven lines"). Important: effective specifically for dynamic (mimic) wrinkles, not for static ones.

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Safe alternative to botulinum

Unlike botulinum toxin (botox): does not completely block the synapse, but only reduces the amplitude of contraction → natural facial expression is preserved. Does not penetrate systemically (large molecule, topical application). No risk of "frozen face" or swallowing difficulties. Suitable for those who want a milder effect or are not ready for injections. Can complement the effect of botox — studies show a synergistic effect.

✧

Prevention of new wrinkles

Regular use reduces the intensity of muscle contractions over time → reduces the "fixation" of mimic folds in the form of deep wrinkles. Especially effective in prevention: start at 25–35 years old, when wrinkles are still superficial. Synergy: with palmitoyl pentapeptide-4 (collagen stimulation) + retinol (cell renewal) — a comprehensive anti-aging approach.

Suitable for

mature skinskin with mimic wrinklespreventive care 25+

Main Actions

✓ myorelaxing effect on mimic muscles✓ reduction of dynamic wrinkles✓ prevention of new wrinkles

Acetyl Hexapeptide-3 vs Acetyl Hexapeptide-8

Acetyl Hexapeptide-3: original Argireline — without a lipid tail, water-soluble. Acetyl Hexapeptide-8: Argireline Amplified — with palmitic acid → better penetration into the stratum corneum, potentially more effective at lower concentrations. In INCI: "Acetyl Hexapeptide-3" or "Acetyl Hexapeptide-8". In practice, both ingredients are sold as Argireline or Argireline Amplified. Effective concentration: 5–10%. <1% — marketing "trace".

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