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Emollient

Acetyl Dipeptide-1 Cetyl Ester

Calmosensine — a peptide against skin stress and fatigue. It blocks pain and stress receptors (CGRP pathway), reducing chronic inflammation from neurogenic stress. It restores a "calm" appearance to the skin after exhaustion and chronic stress.

Calmosensineanti-stressneuropeptideCGRP
✓ Safe
Comedogenic Rating
0/5
Irritation Potential
0/5

What is it?

Acetyl Dipeptide-1 Cetyl Ester — cetyl ester of acetylated dipeptide (Ac-Tyr-Arg-OC16). Trade name Calmosensine® (Sederma). Mechanism: antagonist or modulator of CGRP receptors in the skin. CGRP — a neuropeptide released during stress and pain → neurogenic inflammation, redness, increased skin sensitivity. Calmosensine blocks this signaling pathway. Effective concentration: 0.5–1%. INCI: Acetyl Dipeptide-1 Cetyl Ester.

Products for sensitive skin, anti-stress formulas, products to improve the "rested" appearance of the skin. Especially relevant in combination with night creams and masks.

Key Benefits

✦
Reduction of neurogenic inflammation — the "calming" mechanism
Stress, lack of sleep, and pollution activate the CGRP pathway in the skin — neurogenic inflammation without visible external cause. Result: increased reactivity, redness, tightness. Calmosensine blocks CGRP receptors → reduces neurogenic inflammation → skin becomes less reactive and calmer. The effect is noticeable after just 2–4 weeks of regular use.
◈
Restoration of the "rested" skin appearance
Sederma study: 1% Calmosensine vs placebo — significant improvement in the appearance of "exhausted, stressed skin." Evaluators noted: less dull tone, less visible fatigue, more lifted appearance. Mechanism — reduction of chronic neuroinflammation that suppresses normal cell function.
✧
Synergy with other soothing components
Calmosensine (CGRP blockade) + bissabolol (inflammation) + panthenol (restoration) + ectoin (osmoprotection) = complete anti-stress complex. Especially effective in night products, where the skin recovers from daily stress. Well combined with adaptogens (ashwagandha, rhodiola) in next-generation formulas.

Suitable for

sensitive skinreactive skinskin prone to rednessskin in stress

Main Actions

✓ reduction of neurogenic inflammation✓ calming of reactive skin✓ restoration of appearance
Neurocosmetics — a new direction

Neurocosmetics (neurocosmetics) — products that affect neural transmission in the skin. The nervous system of the skin plays a huge role in its reactions and aging. Calmosensine is the first widely known neuropeptide of this class. Along with Argireline (neuromuscular block) and Leuphasyl (opioid modulation) — a new wave of cosmetic peptides acting through neural mechanisms.

CategoryEmollients

Frequently Asked Questions

What does Acetyl Dipeptide-1 Cetyl Ester do for skin?
Products for sensitive skin, anti-stress formulas, products to improve the "rested" appearance of the skin. Especially relevant in combination with night creams and masks.
Who should use Acetyl Dipeptide-1 Cetyl Ester?
Acetyl Dipeptide-1 Cetyl Ester is suitable for: sensitive skin, reactive skin, skin prone to redness, skin in stress.
Are there any warnings about Acetyl Dipeptide-1 Cetyl Ester?
Neurocosmetics (neurocosmetics) — products that affect neural transmission in the skin. The nervous system of the skin plays a huge role in its reactions and aging. Calmosensine is the first widely known neuropeptide of this class. Along with Argireline (neuromuscular block) and

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